The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults

Lamport, Daniel J. and Pal, Deepa and Macready, Anna L. and Barbosa-Boucas, Sofia and Fletcher, John M. and Williams, Claire M. and Spencer, Jeremy P. E. and Butler, Laurie T. (2017) The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults. British Journal of Nutrition, 116 (12). pp. 2160-2168. ISSN 1475-2662

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Official URL: https://doi.org/10.1017/S000711451600430X

Abstract

A plausible mechanism underlying flavonoid-associated cognitive effects is increased cerebral blood flow (CBF). However, behavioural and CBF effects following flavanone-rich juice consumption have not been explored. The aim of this study was to investigate whether consumption of flavanone-rich juice is associated with acute cognitive benefits and increased regional CBF in healthy, young adults. An acute, single-blind, randomised, cross-over design was applied with two 500-ml drink conditions - high-flavanone (HF; 70·5 mg) drink and an energy-, and vitamin C- matched, zero-flavanone control. A total of twenty-four healthy young adults aged 18-30 years underwent cognitive testing at baseline and 2-h after drink consumption. A further sixteen, healthy, young adults were recruited for functional MRI assessment, whereby CBF was measured with arterial spin labelling during conscious resting state at baseline as well as 2 and 5 h after drink consumption. The HF drink was associated with significantly increased regional perfusion in the inferior and middle right frontal gyrus at 2 h relative to baseline and the control drink. In addition, the HF drink was associated with significantly improved performance on the Digit Symbol Substitution Test at 2 h relative to baseline and the control drink, but no effects were observed on any other behavioural cognitive tests. These results demonstrate that consumption of flavanone-rich citrus juice in quantities commonly consumed can acutely enhance blood flow to the brain in healthy, young adults. However, further studies are required to establish a direct causal link between increased CBF and enhanced behavioural outcomes following citrus juice ingestion.

Item Type: Journal Article
Keywords: CBF cerebral blood flow, CT control, DSST Digit Symbol Substitution Test, HF high flavanone, fMRI functional MRI, Cerebral blood flow, Cognition, Cognitive function, Flavonoids, Functional MRI, Juices
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Lisa Blanshard
Date Deposited: 26 Feb 2020 15:54
Last Modified: 26 Feb 2020 15:56
URI: http://arro.anglia.ac.uk/id/eprint/705228

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