The plateau at V˙ O2max is associated with anaerobic alleles

Keiller, Don and Gordon, Dan (2020) The plateau at V˙ O2max is associated with anaerobic alleles. Journal of Science and Medicine in Sport, 23 (5). pp. 506-511. ISSN 1878-1861

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Objectives: This study tests the hypothesis that individuals who achieve a plateau at V˙ O2max (V˙ O2plat) are more likely to possess alleles, associated with anaerobic capacity, than those who do not. Design: A literature survey, physiological testing and genetic analysis was used to determine any association between the aerobic and anaerobic polymorphisms of 40 genes and V˙ O2plat. Methods: 34, healthy, Caucasian volunteers, completed an exercise test to determine V˙ O2max, and V˙ O2plat. 28 of the volunteers agreed to DNA testing and 26 were successfully genotyped. A literature search was used to determine whether the 40 polymorphisms analysed were associated with aerobic, or anaerobic exercise performance. Results: The literature survey enabled classification of the 40 target alleles as aerobic [11], anaerobic [24], or having no apparent association (NAA) [5] with exercise performance. It also found no previous studies linking a genetic component with the ability to achieve V˙ O2plat. Independent t-tests showed a significant difference (p < 0.001) in the ability to achieve V˙ O2plat, but no other measured physiological variable was significantly different. Pearson's χ2 testing demonstrated a highly significant association (p = 0.008) between anaerobic allele frequency and V˙ O2plat, but not with V˙ O2max. There was no association between aerobic alleles and V˙ O2plat, or V˙ O2max. Finally there were no significant differences in the allelic frequencies, observed in this study and those expected of Northern and Western European Caucasians. Conclusion: These results support the hypothesis that the ability to achieve V˙ O2plat is associated with alleles linked to anaerobic exercise capacity.

Item Type: Journal Article
Keywords: Anaerobic capacity, Exercise performance, Oxygen consumption, Polymorphism
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 19 Feb 2020 10:36
Last Modified: 09 Sep 2021 18:53

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