Development, characterization and stability evaluation of ciprofloxacin-loaded parenteral nutrition nanoemulsions

Said Suliman, Ammar and Tom, Rose and Palmer, Kirsty and Tolaymat, Ibrahim and Younes, Husam M. and Arafat, Basel and Elhissi, Abdelbary M. A. and Najlah, Mohammad (2020) Development, characterization and stability evaluation of ciprofloxacin-loaded parenteral nutrition nanoemulsions. Pharmaceutical Development and Technology, 25 (5). pp. 579-587. ISSN 1083-7450

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In this study, two licensed total parenteral nanoemulsion formulations (Clinoleic® and Intralipid®) were loaded with ciprofloxacin (CP). The physicochemical characteristics and stability profiles of the formulations were investigated using a range of drug concentrations. Furthermore, formulation stability was evaluated over a period of six months at room temperature or 4 °C. Loading CP into nanoemulsions resulted in no significant differences in their measured droplet size, polydispersity index (PI), zeta potential and pH. Drug entrapment efficiency (EE) was relatively high for all formulations, regardless of nanoemulsion type, and the drug release was sustained over 24 h. Stability studies of all formulations were performed at 4 °C and room temperature (RT) for 180 and 60 days, respectively. At 4 °C for 180 days, both Clinoleic and Intralipid formulations at a range of drug concentrations (1-10 mg/ml) showed high stabilities measured periodically by the average droplet sizes, PI, pH and zeta potential values. Similar results, but pH values, were shown when the formulations for both nanoemulsion stored at RT for 60 days. Overall, this study has shown that CP was successfully loaded into clinically licensed TPN lipid nanoemulsions. The resultant CP-loaded nanoemulsion formulations demonstrated desirable physicochemical properties and were stable upon storage at 4 °C for up to six months.

Item Type: Journal Article
Keywords: ciprofloxacin, droplet size, nanoemulsion, polydispersity index, stability, zeta potential
Faculty: Faculty of Health, Education, Medicine & Social Care
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 12 Feb 2020 10:47
Last Modified: 09 Sep 2021 18:53

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