Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and meta-analysis

Pizzol, Damiano and Smith, Lee and Fontana, Luigi and Caruso, Maria G. and Bertoldo, Alessandro and Demurtas, Jacopo and McDermott, Daragh T. and Garolla, Andrea and Grabovac, Igor and Veronese, Nicola (2020) Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and meta-analysis. Reviews in Endocrine and Metabolic Disorders, 21. pp. 657-666. ISSN 1573-2606

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Background: Growing evidence reports that obesity might play a role in erectile dysfunction (ED), but limited knowledge is available. We conducted a meta-analysis to estimate the prevalence of ED in overweight men and men with obesity.   Methods: We performed a systematic review up to 01/04/2019 to investigate the associations be-tween obesity and ED. Applying a random-effect model, we calculated the prevalence of ED, the odds ratio (OR) for the presence of ED by Body Mass Index (BMI) categories and the mean differ-ences between ED and controls in BMI and Waist Circumference (WC). Results: Among 3409 studies, we included 45 articles with 42,489 men (mean age=55 years). Taking normal weight men as reference, the prevalence of ED was significantly higher in overweight (OR=1.31; 95%CI: 1.13-1.51; I2=72%) and in men with obesity (OR=1.60; 95%CI: 1.29-1.98; I2=79%). Adjusting our analyses for potential confounders, the results were confirmed in men with obesity (OR=1.46; 95%CI: 1.24-1.72; I2=72%). ED was associated with significant higher values of BMI (MD=0.769; 95%CI: 0.565-0.973 Kg/m2; I2=78%) and WC (MD=5.251 cm; 95%CI: 1.295-9.208; I2=96%). Discussion: Considering the high prevalence of ED among men with obesity, clinicians should screen for this clinical condition in this population. Findings from the present study suggest that re-ducing adiposity is a crucial approach in patients with ED who are affected by obesity.

Item Type: Journal Article
Keywords: obesity, body mass index, waist, erectile dysfunction, meta-analysis
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 20 Jan 2020 14:53
Last Modified: 09 Sep 2021 18:53

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