Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies

Brokmeier, Luisa and Firth, Joseph and Vancampfort, Davy and Smith, Lee and Deenik, Jeroen and Rosenbaum, Simon and Stubbs, Brendon and Schuch, Felipe (2020) Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies. Psychiatry Research, 284. p. 112675. ISSN 1872-7123

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Longitudinal prospective cohorts have suggested that physical activity (PA) may be a protective factor against psychosis and schizophrenia. However, no meta-analysis has been conducted. The study aims to To examine the prospective relationship between PA and incident psychosis/schizophrenia. Major databases were searched from inception to July 2019 for prospective studies that calculated the odds ratio (OR) or the adjusted odds ratio (AOR) of incident psychosis/schizophrenia in people with higher PA against people with lower PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted, for OR and AOR, separately. Across 4 cohorts (N=30,025, median males=50%, median follow-up=32 years), people with high self-reported PA (versus low PA) were at reduced odds of developing psychosis/schizophrenia (OR=0.73, 95%CI 0.532 to 0.995, p=0.047). Analysis including only 2 cohorts presenting AOR were not statistically significant (AOR=0.59, 95%CI 0.253 to 1.383, p=0.226). Overall study quality was moderate high (mean NOS=7.,0). The literature on the topic is scarce, whilst crude analysis suggests that PA may be a protective factor against the emergence of psychosis/schizophrenia, but when adjusting for covariates, the association is no longer significant. Further studies with objective physical activity and adjustment for confounders are needed.

Item Type: Journal Article
Keywords: Physical activity, Psychosis, Meta-analysis
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 04 Nov 2019 09:39
Last Modified: 09 Sep 2021 18:53

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