Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

Toor, Iqbal S. and Ruckerl, Dominik and Mair, Iris and Ainsworth, Rob and Meloni, Marco and Spiroski, Ana-Mishel and Benezech, Cecile and Felton, Jennifer M. and Thomson, Adrian and Caporali, Andrea and Keeble, Thomas R. and Tang, Kare H. and Rossi, Adriano G. and Newby, David E. and Allen, Judith E. and Gray, Gillian A. (2020) Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction. JACC: Basic to Translational Science, 5 (7). pp. 665-681. ISSN 2452-302X

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Official URL: https://doi.org/10.1016/j.jacbts.2020.05.005

Abstract

In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.

Item Type: Journal Article
Keywords: ST-segment elevation myocardial infarction, macrophages, CD206, IL-4, eosinophil, remodeling, STEMI
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Ian Walker
Date Deposited: 23 Sep 2019 09:12
Last Modified: 01 Oct 2020 15:38
URI: https://arro.anglia.ac.uk/id/eprint/704783

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