Differences in serum magnesium levels in diabetic and non-diabetic patients following one-anastomosis gastric bypass

Winzer, Eva, Grabovac, Igor, Ludvik, Bernhard, Kruschitz, Renate, Schindler, Karin, Prager, Gerhard, Klammer, Carmen, Smith, Lee, Hoppichler, Friedrich, Marculescu, Rodrig and Wakolbinger, Maria (2019) Differences in serum magnesium levels in diabetic and non-diabetic patients following one-anastomosis gastric bypass. Nutrients, 11 (9). p. 1984. ISSN 2072-6643

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Abstract

Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass surgery. Overall, 50 patients (80% female, age 42.2 (12.5) years) with morbid obesity (mean baseline BMI 43.8 (4.3) kg/m2) were included in the analysis. Half of the included patients had T2DM diagnosed at baseline, and these patients showed lower serum Mg concentration (0.78 (0.07)) vs. 0.83 (0.05) mmol/L; p = 0.006), higher blood glucose levels (129.9 (41.3) vs. 87.6 (8.1) mg/dL; p < 0.001) as well as HbA1c concentrations (6.7 (1.4) vs. 5.3 (0.5)%; p < 0.001). During follow-up, BMI and glucose levels showed a decrease; however, serum Mg levels remained stable. At baseline 42% of patients were found to be Mg deficient, which was reduced to 33% at six months and to 30% at 12 months follow-up. Moreover, patients with T2DM had an odds ratio of 9.5 (95% CI = 3.0–29.7; p < 0.001) for magnesium deficiency when compared to patients without T2DM. Further research into the role of Mg and its role in T2DM and other obesity-related comorbidities are needed.

Item Type:	Journal Article
Keywords:	serum magnesium, obesity, type 2 diabetes mellitus, one anastomosis gastric bypass
Faculty:	Faculty of Science & Engineering
Depositing User:	Lee Smith
Date Deposited:	19 Aug 2019 14:23
Last Modified:	09 Sep 2021 18:54
URI:	https://arro.anglia.ac.uk/id/eprint/704653

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