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The Activation Status of the TGF-β Transducer Smad2 is Associated with a Reduced Survival in Gastrointestinal Cancers: a Systematic Review and Meta-Analysis

journal contribution
posted on 2023-09-01, 14:32 authored by Ilaria Girolami, Nicola Veronese, Lee Smith, Maria Gabriella Caruso, Rosa Reddavide, Gioacchino Leandro, Jacopo Demurtas, Alessia Nottegar
Aberrant function of Smad2, a crucial member of the transforming growth factor beta (TGF-β) signalling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05–2.37, p = 0.029, I2 = 84%), also after having adjusted for potential confounders (RR, 1.65; 95% CI, 1.24–2.18; p < 0.001; I2 = 4%). This finding highlights the importance of the TGF-β signaling in this type of cancers. In this line, further studies are needed to explore more in depth this important molecular pathway, focusing also on potential therapeutic strategies based on its effectors or molecular targets.

History

Refereed

  • Yes

Volume

20

Issue number

15

Page range

3831

Publication title

International Journal of Molecular Sciences

ISSN

1422-0067

Publisher

MDPI

File version

  • Accepted version

Language

  • eng

Legacy posted date

2019-08-02

Legacy creation date

2019-08-01

Legacy Faculty/School/Department

Faculty of Science & Engineering

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