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The relationship between dietary vitamin K and depressive symptoms in late adulthood: a cross-sectional analysis from a large cohort study

journal contribution
posted on 2023-09-01, 14:27 authored by Francesco Bolzetta, Nicola Veronese, Brendon Stubbs, Marianna Noale, Alberto Vaona, Jacopo Demurtas, Stefano Celotto, Chiara Cacco, Alberto Cester, Maria G. Caruso, Rosa Reddavide, Maria Notarnicola, Stefania Maggi, Ai Koyanagi, Michele Fornaro, Joseph Firth, Lee Smith, Marco Solmi
Few studies assessed associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants aged 45-79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) > 16. To investigate associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, adjusting for potential confounders. Overall 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR=0.58; 95%CI: 0.43-0.80). This effect was present only in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association.

History

Refereed

  • Yes

Volume

11

Issue number

4

Page range

787

Publication title

Nutrients

ISSN

2072-6643

Publisher

MDPI

File version

  • Accepted version

Language

  • eng

Legacy posted date

2019-04-01

Legacy creation date

2019-03-29

Legacy Faculty/School/Department

Faculty of Science & Engineering

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