Schutte_2019.doc (363 kB)
Aldosterone and renin in relation to surrogate measures of sympathetic activity: the SABPA study
journal contribution
posted on 2023-08-30, 16:02 authored by Lebo F. Gafane-Matemane, Johannes M. van Rooyen, Rudolph Schutte, Aletta E. SchutteINTRODUCTION: Hypertension, particularly in black populations, is often accompanied by augmented sympathetic nervous system activity and suppressed renin activity, indicative of possible blood pressure (BP) dysregulation. The potential role of the interrelationship between the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system in the context of low-renin conditions is unclear. We therefore explored whether surrogate measures of sympathetic activity [noradrenaline, 24-hour heart rate (HR) and percentage (%) dipping of night-time HR] relate to renin, aldosterone and aldosterone-to-renin ratio (ARR) in black and white South Africans. METHODS:We included black (n = 127) and white (n = 179) males and females aged 20-63 years. We measured 24-hour BP and HR, and calculated night-time dipping. We determined renin and aldosterone levels in plasma and calculated ARR. Noradrenaline and creatinine levels were determined in urine and the noradrenaline:creatinine ratio was calculated. RESULTS:More blacks had low renin levels (80.3%) compared to whites (58.7%) (p < 0.001). In univariate and after multivariate analyses the following significant associations were evident in only the black group: HR dipping was associated negatively with aldosterone level (β = -0.18, p = 0.024) and ARR (β = -0.20, p = 0.011), while 24-hour HR was associated positively with renin level (β = 0.20, p = 0.024). Additionally, there was a borderline significant positive association between noradrenaline:creatinine ratio and aldosterone level (β = 0.19, p = 0.051). CONCLUSIONS:The observed associations between surrogate measures of sympathetic nervous system activity and components of the RAAS in the black group suggest that the adverse effects of aldosterone and its ratio to renin on the cardiovascular system may be coupled to the effects of the sympathetic nervous system.
History
Refereed
- Yes
Volume
30Page range
1-7Publication title
Cardiovascular Journal of AfricaISSN
1680-0745External DOI
Publisher
Clinics CardiveFile version
- Accepted version
Language
- eng
Legacy posted date
2019-02-14Legacy creation date
2019-02-13Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC