Aspinall_Lang_2018.pdf (431.13 kB)
Interventions to restore appropriate immune function in the elderly
journal contribution
posted on 2023-07-26, 14:32 authored by Richard Aspinall, Pierre-Olivier LangAdvanced age is one indicator of likely immune dysfunction. As worldwide, the global population contains progressively more and more older individuals there is likelihood of an increased prevalence and incidence of infectious diseases due to common and emergent pathogens. The resultant increase in mortality and morbidity would be matched by the risk of functional decline and disability. Maintaining immune function at a plateau throughout life may therefore be associated with considerable cost savings. The aim of improving immune function in older individuals may be achieved through considering a therapeutic approach to rejuvenate, stimulate or support the indigenous immune system to perform in a more optimal manner. In terms of cost effectiveness a therapeutic approach may prove difficult because of issues associated with; identifying those who would benefit the most from this treatment, identifying the type of treatment which would suit them and identifying whether the treatment was successful. The alternative of supporting or providing a stronger stimulus through vaccination, whilst more cost effective, may be a more valuable option in the short term. Both approaches will be addressed in this review.
History
Refereed
- Yes
Volume
15Issue number
5Number of pages
8Publication title
Immunity & AgeingISSN
1742-4933External DOI
Publisher
BioMed CentralFile version
- Published version
Language
- eng
Official URL
Legacy posted date
2019-01-29Legacy creation date
2019-01-24Legacy Faculty/School/Department
ARCHIVED Faculty of Health, Social Care & Education (until September 2018)Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC