Angiotensin-converting-enzyme inhibitors use and incident frailty: A longitudinal cohort study

Veronese, Nicola and Stubbs, Brendon and Smith, Lee and Maggi, Stefania and Jackson, Sarah E. and Soysal, Pinar and Demurtas, Jacopo and Celotto, Stefano and Koyanagi, Ai (2019) Angiotensin-converting-enzyme inhibitors use and incident frailty: A longitudinal cohort study. Drugs and Aging, 36 (4). pp. 387-393. ISSN 1179-1969

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Introduction: Angiotensin-converting-enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals. Methods: Data from the Osteoarthritis Initiative, a cohort study with 8 years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. ACEI use was defined through self-reported information and confirmed by a trained interviewer. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of at least two of the following criteria: (i) weight loss ≥5% between baseline and any subsequent follow-up visit; (ii) inability to do five chair stands; and (iii) low energy level according to the SOF definition. A multivariable Poisson regression analysis was used to assess the association between ACEI use at baseline and incident frailty. The data were reported as relative risks (RRs) with their 95% confidence intervals (CIs). Results: The final sample consisted of 4,295 adults (mean age 61.2 years, females=58.1%). At baseline, 551 participants (12.8%) used ACEI. After adjusting for 15 potential confounders, the use of ACEI was associated with a lower risk of frailty (RR=0.72; 95%CI: 0.53-0.99). The adjustment for the propensity score substantially confirmed these findings (RR=0.75; 95%CI: 0.54-0.996). Conclusion: ACEI use may be associated with a reduced risk of frailty in individuals with/at risk of knee osteoarthritis, suggesting a potential role for ACI in the prevention of frailty.

Item Type: Journal Article
Keywords: angiotensin-converting-enzyme inhibitors, aged, frailty
Faculty: Faculty of Science & Engineering
Depositing User: Lee Smith
Date Deposited: 22 Jan 2019 10:02
Last Modified: 09 Sep 2021 18:55

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