Koyanagi, Ai and Oh, Hans and Vancampfort, Davy and Carvalho, Andre F. and Veronese, Nicola and Stubbs, Brendon and Lara, Elvira (2019) Perceived Stress and Mild Cognitive Impairment among 32,715 Community-Dwelling Older Adults across Six Low- and Middle-Income Countries. Gerontology, 65. pp. 155-163. ISSN 1423-0003
Full text not available from this repository.Abstract
Background: Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. Objective: We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa) using nationally representative data. Methods: Cross-sectional, community-based data on individuals aged ≥50 years from the World Health Organization’s Study on Global Ageing and Adult Health were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer’s Association criteria. A perceived stress score (range 0 [lowest stress] to 10 [highest stress]) was computed based on two questions from the Perceived Stress Scale. Multivariable logistic regression analysis was conducted to assess the association between perceived stress and MCI. Results: The mean (SD) age of the 32,715 participants was 62.1 (15.6) years and 51.7% were females. After adjustment for potential confounders including depression, in the overall sample, a one-unit increase in the perceived stress score was associated with a 1.14 (95% CI = 1.11–1.18) times higher odds for MCI. The association was similar among those aged 50–64 and ≥65 years. Countrywise analysis showed that there was a moderate level of between-country heterogeneity in this association (I2 = 59.4%), with the strongest association observed in Russia (OR = 1.33, 95% CI = 1.15–1.55). Conclusion: If our study results are confirmed in prospective studies, addressing perceived stress may have an impact in reducing the risk for MCI and subsequent dementia in LMICs.
| Item Type: | Journal Article |
|---|---|
| Keywords: | Cognition, Perceived stress, Risk factor |
| Faculty: | ARCHIVED Faculty of Health, Social Care & Education (until September 2018) |
| Depositing User: | Lisa Blanshard |
| Date Deposited: | 17 Jan 2019 12:13 |
| Last Modified: | 09 Sep 2021 16:09 |
| URI: | https://arro.anglia.ac.uk/id/eprint/704024 |
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