Magnesium and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational and intervention studies

Veronese, Nicola and Demurtas, Jacopo and Pesolillo, Gabriella and Cletto, Stefano and Barnini, Tommaso and Calusi, Giovanni and Caruso, Maria Gabriella and Notarnicola, Maria and Reddavide, Rosa and Stubbs, Brendon and Solmi, Marco and Maggi, Stefania and Vaona, Alberto and Firth, Joseph and Smith, Lee and Koyanagi, Ai and Dominguez, Ligia and Barbagallo, Mario (2020) Magnesium and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational and intervention studies. European Journal of Nutrition, 59. pp. 263-272. ISSN 1436-6215

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Purpose: To map and grade all health outcomes associated with Magnesium (Mg) intake using an umbrella review. Methods: Umbrella review of systematic reviews with meta-analyses of observational studies and randomised controlled trials (RCTs) using placebo/no intervention as control group. We assessed meta-analyses of observational studies based on random-effects summary effect sizes and their P-values, 95% prediction intervals, heterogeneity, small-study effects and excess significance. For meta-analyses of RCTs, outcomes with a random effects P-value <0.005 and a high GRADE assessment, were classified as strong evidence. Results: From 2,048 abstracts, 16 meta-analyses and 55 independent outcomes were included (36 in RCTs and 19 in observational studies). In RCTs of Mg versus placebo/no active treatment, 12 over 36 outcomes reported significant results (p<0.05). A strong evidence for decreased need for hospitalization in pregnancy and for decreased risk of frequency and intensity of migraine relapses in people with migraine was observed using the GRADE assessment. In observational studies, 9/19 outcomes were significant (p<0.05). However, only one outcome presented highly suggestive evidence (lower incidence of type 2 diabetes in people with higher Mg intake at baseline) and one suggestive (lower incidence of stroke associated with higher Mg intake at baseline). Conclusion: Strong evidence according to the GRADE suggests that Mg supplementation can decrease the risk of hospitalization in pregnant women and reduce the intensity/frequency of migraine. Higher Mg intake is associated with a decreased risk of type 2 diabetes and stroke with highly suggestive and suggestive evidence, respectively, in observational studies.

Item Type: Journal Article
Keywords: Magnesium, Health Oucomes, Umbrella Review
Faculty: Faculty of Science & Engineering
Depositing User: Lee Smith
Date Deposited: 18 Jan 2019 12:01
Last Modified: 09 Sep 2021 18:54

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