Physical activity modifies the association between depression and cognitive function in older adults

Hu, Liang and Smith, Lee and Imm, Kellie R. and Jackson, Sarah E. and Yang, Lin (2019) Physical activity modifies the association between depression and cognitive function in older adults. Journal of Affective Disorders, 246. pp. 800-805. ISSN 1573-2517

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Objective: To examine the effects of gender and physical activity on the interplay between depression and cognitive function in late adulthood. Method: Data on physical activity, depressive symptoms, two measures of cognitive function (the Animal Fluency Test (AFT) and the Digital Symbol Substitution Test (DSST)), and other demographic characteristics were extracted from 2,604 adults aged ≥ 60 years participating in the National Health and Nutrition Examination Survey (2011-2014). Gender-specific multiple linear regressions examined the relationship between depressive symptoms and cognitive function in the overall sample and stratified by level of leisure-time physical activity. Results: Sample included 1327 women and 1277 men (mean age 69.0 years), Women with moderate to severe depressive symptoms had a 1.7 (95% CI: 0.5 to 2.9) point lower score on the AFT than those with none or minimal depressive symptoms. No such association was observed in men. In the stratified analyses, lower AFT test scores only persisted among women who were inactive. With respective to the DSST, lower test scores were observed in in both men (-7.2, 95% CI: -13.1 to -1.3) and women (-6.4, 95% CI: -11.8 to -1.1) with moderate to severe depressive symptoms. In the stratified analyses, this association persisted in those who were insufficiently active, but attenuated to null among those engaged in sufficient physical activity. Conclusions: Moderate-to-vigorous physical activity modifies the depression-cognition relationship and preserves cognition function. Engaging in sufficient (150 min/week) leisure-time physical activity at moderate-to-vigorous intensity may protect those with depressive symptoms from cognitive decline in older age.

Item Type: Journal Article
Keywords: Older Adults, Physical Activity, Depressive Symtpoms, Cognitive Function
Faculty: Faculty of Science & Engineering
Depositing User: Lee Smith
Date Deposited: 07 Jan 2019 10:13
Last Modified: 09 Sep 2021 18:55

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