Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis

Chu, Che-Sheng and Tseng, Ping-Tao and Stubbs, Brendon and Chen, Tien-Yu and Tang, Chia-Hung and Li, Dian-Jeng and Yang, Wei-Cheng and Chen, Yen-Wen and Wu, Ching-Kuan and Veronese, Nicola and Carvalho, Andre F. and Fernandes, Brisa S. and Herrmann, Nathan and Lin, Pao-Yen (2018) Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis. Scientific Reports, 8. p. 5804. ISSN 2045-2322

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We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556–0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.

Item Type: Journal Article
Keywords: statins
Faculty: ARCHIVED Faculty of Health, Social Care & Education (until September 2018)
Depositing User: Lisa Blanshard
Date Deposited: 20 Nov 2018 11:28
Last Modified: 09 Sep 2021 18:57

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