Anglia Ruskin Research Online (ARRO)
Browse
RCP2018_KeebleFINALmanuscript.docx (59.23 kB)

Percutaneous haemodynamic and renal support in patients presenting with decompensated heart failure: A multi-centre efficacy study using the Reitan Catheter Pump (RCP)

Download (59.23 kB)
journal contribution
posted on 2023-08-30, 15:43 authored by Thomas R. Keeble, Grigoris V. Karamasis, Martin T. Rothman, Sven-Erik Ricksten, Markus Ferrari, Roger Hullin, Fredrik Scherstén, Oyvind Reitan, Sebastian T. Kirking, John G. F. Cleland, Elliot J. Smith
Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction < 30%, and Cardiac index (CI) < 2.1 L/min/m2 in need of inotropic/mechanical support. Results: Patients underwent RCP support for a mean of 18.3 (±6.3) hours. The RCP increased CI from 1.84 L/min/m2 (±0.27), to 2.41 L/min/m2 (±0.45, p = 0.04), increased urine output (71 mL/h (±65) to 227 ml/h (±179) (p = 0.006) with a concomitant reduction in serum creatinine (188 μmol/L (±87) to 161 μmol/L (±78) (p = 0.0007). There were no clinically significant haemolysis, vascular injury, or thrombo-embolic complications. Conclusions: For patients admitted with DHF, the RCP improves cardiac index, diuresis and renal function without causing important complications.

History

Refereed

  • Yes

Volume

275

Page range

53-58

Publication title

International Journal of Cardiology

ISSN

1874-1754

Publisher

Elsevier

File version

  • Accepted version

Language

  • eng

Legacy posted date

2018-10-23

Legacy creation date

2018-12-13

Legacy Faculty/School/Department

Faculty of Health, Education, Medicine & Social Care

Usage metrics

    ARU Outputs

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC