Regulation of low-density lipoprotein cholesterol by intestinal inflammation and the acute phase response

Herbert, Karl and Erridge, Clett (2018) Regulation of low-density lipoprotein cholesterol by intestinal inflammation and the acute phase response. Cardiovascular Research, 114 (2). pp. 226-232. ISSN 1755-3245

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Systemic inflammation, induced by disease or experimental intervention, is well established to result in elevated levels of circulating triglycerides, and reduced levels of high-density lipoprotein-cholesterol (HDL-C), in most mammalian species. However, the relationship between inflammation and low-density lipoprotein-cholesterol (LDL-C) concentrations is less clear. Most reports indicate that systemic inflammation, as observed during sepsis or following high dose experimental endotoxaemia, lowers total and LDL-C in man. However, isolated reports have suggested that certain inflammatory conditions are associated with increased LDL-C. In this review, we summarise the emerging evidence that low-grade inflammation specifically of intestinal origin may be associated with increased serum LDL-C levels. Preliminary insights into potential mechanisms that may mediate these effects, including those connecting inflammation to trans-intestinal cholesterol efflux (TICE), are considered. We conclude that this evidence supports the potential downregulation of major mediators of TICE by inflammatory mediators in vitro and during intestinal inflammation in vivo. The TICE-inflammation axis therefore merits further study in terms of its potential to regulate serum LDL-C, and as a readily druggable target for hypercholesterolaemia.

Item Type: Journal Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in 'Cardiovascular Research' following peer review. The version of record is available online at:10.1093/cvr/cvx237
Keywords: cholesterol, inflammation, endotoxin, trans-intestinal
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Ian Walker
Date Deposited: 04 Dec 2017 09:21
Last Modified: 09 Sep 2021 18:57

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