Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis

Lucato, Paola, Solmi, Marco, Maggi, Stefania, Bertocco, Anna, Bano, Giulia, Trevisan, Caterina, Manzato, Enzo, Sergi, Giuseppe, Schofield, Patricia, Kouidrat, Youssef, Veronese, Nicola and Stubbs, Brendon (2017) Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis. Maturitas, 100. pp. 8-15. ISSN 1873-4111

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Official URL: https://doi.org/10.1016/j.maturitas.2017.02.016


Low serum levels of 25 hydroxyvitamin D (25OHD) (hypovitaminosis D) is common in older adults and associated with several negative outcomes. The association between hypovitaminosis D and diabetes in older adults is equivocal, however. We conducted a meta-analysis investigating if hypovitaminosis D is associated with diabetes in prospective studies among older participants. Two investigators systematically searched major electronic databases, from inception until 10/07/2016. The cumulative incidence of diabetes among groups was estimated according to serum 25OHD levels. Random effect models were used to assess the association between hypovitaminosis D and diabetes at follow-up. From 4,268 non-duplicate hits, 9 studies were included; these followed 28,258 participants with a mean age of 67.7 years for a median of 7.7 years. Compared with higher levels of 25OHD, lower levels of 25OHD were associated with a higher risk of developing diabetes (6 studies; n = 13,563; RR = 1.31; 95% CI: 1.11–1.54; I2 = 37%). The findings remained significant after adjusting for a median of 11 potential confounders in all the studies available (9 studies; n = 28,258; RR = 1.17; 95% CI: 1.03–1.33; p = 0.02; I2 = 0%). In conclusion, our data suggest that hypovitaminosis D is associated with an elevated risk of future diabetes in older people. Future longitudinal studies are required and should seek to confirm these findings and explore potential pathophysiological underpinnings.

Item Type: Journal Article
Keywords: Vitamin D, Diabetes, Older people
Faculty: ARCHIVED Faculty of Health, Social Care & Education (until September 2018)
Depositing User: Brendon Stubbs
Date Deposited: 24 Mar 2017 15:49
Last Modified: 09 Sep 2021 18:58
URI: https://arro.anglia.ac.uk/id/eprint/701597

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