File(s) under permanent embargo
Patients with mild cognitive impairment show lower visual short-term memory performance for feature binding tasks
journal contribution
posted on 2023-09-01, 14:02 authored by Raju P. Sapkota, Ian van der Linde, Nirmal Lamichhane, Tirthalal Upadhyaya, Shahina PardhanBackground: Early cognitive changes in people at risk of developing dementia may be detected using behavioral tests that examine the performance of typically affected brain areas, such as the hippocampi. An important cognitive function supported by the hippocampi is memory binding, in which object features are associated to create a unified percept. Aim: To compare visual short-term memory (VSTM) binding performance for object names, locations, and identities between a participant group known to be at higher risk of developing dementia (mild cognitive impairment [MCI]) and healthily aging controls. Methods: Ten MCI and 10 control participants completed five VSTM tests that differed in their requirement of remembering bound or unbound object names, locations, and identities, along with a standard neuropsychological test (Addenbrooke’s Cognitive Examination [ACE]-III). Results: The performance of the MCI participants was selectively and significantly lower than that of the healthily aging controls for memory tasks that required object-location or name-location binding. Conclusion: Tasks that measure unimodal (object-location) and crossmodal (name-location) binding performance appear to be particularly effective for the detection of early cognitive changes in those at higher risk of developing dementia due to Alzheimer’s disease.
History
Refereed
- Yes
Volume
7Issue number
1Page range
74-86Publication title
Dementia and Geriatric Cognitive Disorders ExtraISSN
1664-5464External DOI
Publisher
Karger PublishersFile version
- Accepted version
Language
- eng
Official URL
Legacy posted date
2017-01-17Legacy creation date
2017-01-17Legacy Faculty/School/Department
ARCHIVED Faculty of Medical Science (until September 2018)Note
Sapkota, RP., van der Linde, I., Lamichhane, N., Upadhyaya, T., and Pardhan, S. (2017). Patients with mild cognitive impairment show lower visual short-term memory performance for feature binding tasks. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC