Mootanah_2014_2.pdf (5.7 MB)
Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints
journal contribution
posted on 2023-07-26, 14:02 authored by Md J. Nine, Dipankar Choudhury, Ay Ching Hee, Rajshree Mootanah, Noor A. Abu OsmanWear debris, of deferent sizes, shapes and quantities, generated in artificial hip and knees is largely confined to the bone and joint interface. This debris interacts with periprosthetic tissue and may cause aseptic loosening. The purpose of this review is to summarize and collate findings of the recent demonstrations on debris characterization and their biological response that influences the occurrence in implant migration. A systematic review of peer-reviewed literature is performed, based on inclusion and exclusion criteria addressing mainly debris isolation, characterization, and biologic responses. Results show that debris characterization largely depends on their appropriate and accurate isolation protocol. The particles are found to be non-uniform in size and non-homogeneously distributed into the periprosthetic tissues. In addition, the sizes, shapes, and volumes of the particles are influenced by the types of joints, bearing geometry, material combination, and lubricant. Phagocytosis of wear debris is size dependent; high doses of submicron-sized particles induce significant level of secretion of bone resorbing factors. However, articles on wear debris from engineered surfaces (patterned and coated) are lacking. The findings suggest considering debris morphology as an important parameter to evaluate joint simulator and newly developed implant materials.
History
Refereed
- Yes
Volume
7Issue number
2Page range
980-1016Publication title
MaterialsISSN
1996-1944External DOI
Publisher
MDPIFile version
- Published version
Language
- eng
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Legacy posted date
2017-01-25Legacy creation date
2018-11-28Legacy Faculty/School/Department
ARCHIVED Faculty of Science & Technology (until September 2018)Usage metrics
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