A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization

Najlah, Mohammad and Hidayat, Kanar and Omer, Huner K. and Mwesigwa, Enosh and Ahmed, Waqar and AlObaidy, Kais G. and Phoenix, David A. and Elhissi, Abdelbary M. A. (2015) A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization. Journal of Liposome Research, 25 (1). pp. 32-37. ISSN 1532-2394

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Official URL: http://doi.org/10.3109/08982104.2014.924140

Abstract

In this study, a niosome nanodispersion was manufactured using high-pressure homogenization following the hydration of proniosomes. Using beclometasone dipropionate (BDP) as a model drug, the characteristics of the homogenized niosomes were compared with vesicles prepared via the conventional approach of probe-sonication. Particle size, zeta potential, and the drug entrapment efficiency were similar for both size reduction mechanisms. However, high-pressure homogenization was much more efficient than sonication in terms of homogenization output rate, avoidance of sample contamination, offering a greater potential for a large-scale manufacturing of noisome nanodispersions. For example, high-pressure homogenization was capable of producing small size niosomes (209 nm) using a short single-step of size reduction (6 min) as compared with the time-consuming process of sonication (237 nm in >18 min) and the BDP entrapment efficiency was 29.65% ± 4.04 and 36.4% ± 2.8. In addition, for homogenization, the output rate of the high-pressure homogenization was 10 ml/min compared with 0.83 ml/min using the sonication protocol. In conclusion, a facile, applicable, and highly efficient approach for preparing niosome nanodispersions has been established using proniosome technology and high-pressure homogenization.

Item Type: Journal Article
Keywords: Homogenization, niosome, size, sonication, zeta potential
Faculty: ARCHIVED Faculty of Medical Science (until September 2018)
Depositing User: Dr Mohammad Najlah
Date Deposited: 14 Nov 2016 11:07
Last Modified: 09 Sep 2021 16:15
URI: https://arro.anglia.ac.uk/id/eprint/701127

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