The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

Tawari, Patricia E., Wang, Zhipeng, Najlah, Mohammad, Tsang, Chi Wai, Kannappan, Vinodh, Liu, Peng, McConville, Christopher, He, Bin, Armesilla, Angel L. and Wang, Weiguang (2015) The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells. Toxicology Research, 4 (6). pp. 1439-1442. ISSN 2045-4538

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The anticancer activity of disulfiram (DS) is copper(II) (Cu)-depen-dent. This study investigated the anticancer mechanisms of DS/Cuusingin vitrocytotoxicity and metabolic kinetic analysis. Our studyindicates that DS/Cu targets cancer cells by the combination oftwo types of actions: (1) instant killing executed by DS/Cu reactiongenerated reactive oxygen species; (2) delayed cytotoxicity intro-duced by the end product, DDC-Cu. Nanoencapsulation of DSmight shed light on repositioning of DS into cancer treatment.

Item Type: Journal Article
Keywords: disulfiram, cancer cells
Faculty: ARCHIVED Faculty of Medical Science (until September 2018)
Depositing User: Dr Mohammad Najlah
Date Deposited: 14 Nov 2016 11:11
Last Modified: 09 Sep 2021 19:01

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