Mosaic tetracycline resistance genes encoding ribosomal protection proteins

Warburton, Philip J., Amodeo, Nina and Roberts, Adam P. (2016) Mosaic tetracycline resistance genes encoding ribosomal protection proteins. Journal of Antimicrobial Chemotherapy, 71 (12). pp. 3333-3339. ISSN 1460-2091

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First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria.

Item Type: Journal Article
Keywords: genes, ribosomes, tetracycline, resistance, mosaicism
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Ian Walker
Date Deposited: 27 Oct 2016 13:33
Last Modified: 10 Jun 2022 14:47

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