Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood

McCarthy, Hazel, Stanley, Jessica, Piech, Richard M., Skokauskas, Norbert, Mulligan, Aisling, Donohoe, Gary, Mullins, Diane, Kelly, John, Johnson, Katherine, Fagan, Andrew, Gill, Michael, Meaney, James and Frodl, Thomas (2018) Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood. Journal of Attention Disorders, 22 (6). pp. 561-570. ISSN 1557-1246

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Objective: ADHD persists in up to 60% into adulthood, and the reasons for persistence are not fully understood. The objective of this study was to characterize the neurofunctional basis of decision making in those with a childhood diagnosis of ADHD with either persistent or remitted symptoms in adulthood versus healthy control participants. Method: Thirty-two adults diagnosed with ADHD as children were split into persistent (n = 18) or remitted (n = 14) ADHD groups. Their neural activity and neurofunctional connectivity during a probabilistic reversal learning task were compared with 32 healthy controls. Results: Remitters showed significantly higher neural connectivity in final reversal error and probabilistic error conditions, and persisters depict higher neural connectivity in reversal errors than controls at a family-wise error (FWE) corrected whole-brain corrected threshold. Conclusion: Remitters may have utilized higher neural connectivity than controls to make successful decisions. Also, remitters may have utilized compensatory strategies to override any potential underlying ADHD deficits.

Item Type: Journal Article
Keywords: ADHD, remission, persistence, functional neuroimaging
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Dr Richard M. Piech
Date Deposited: 25 Oct 2016 09:50
Last Modified: 10 Feb 2022 16:12

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