Motor Development Interventions for Preterm Infants: A Systematic Review and Meta-analysis

Hughes, Anita J., Redsell, Sarah A. and Glazebrook, Cris (2016) Motor Development Interventions for Preterm Infants: A Systematic Review and Meta-analysis. Pediatrics, 138 (4). e20160147. ISSN 1098-4275

Accepted Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview
Official URL:


CONTEXTS Preterm infants are at an increased risk of neurodevelopmental delay. Some studies report positive intervention effects on motor outcomes, but it is currently unclear which motor activities are most effective in the short and longer term. OBJECTIVE The aim of the study was to identify interventions that improve the motor development of preterm infants. DATA SOURCES An a priori protocol was agreed upon. Seventeen electronic databases from 1980 to April 2015 and gray literature sources were searched. STUDY SELECTION Three reviewers screened the articles. DATA EXTRACTION The outcome of interest was motor skills assessment scores. All data collection and risk of bias assessments were agreed upon by the 3 reviewers. RESULTS Forty-two publications, which reported results from 36 trials (25 randomized controlled trials and 11 nonrandomized studies) with a total of 3484 infants, met the inclusion criteria. A meta-analysis was conducted by using standardized mean differences on 21 studies, with positive effects found at 3 months (mean 1.37; confidence interval 0.48-2.27), 6 months (0.34; 0.11-0.57), 12 months (0.73; 0.20-1.26), and 24 months (0.28; 0.07-0.49). At 3 months, there was a large and significant effect size for motor-specific interventions (2.00; 0.28-3.72) but not generic interventions (0.33; -0.03 to -0.69). Studies were not excluded on the basis of quality; therefore, heterogeneity was significant and the random-effects model was used. LIMITATIONS Incomplete or inconsistent reporting of outcome measures limited the data available for meta-analysis beyond 24 months. CONCLUSIONS A positive intervention effect on motor skills appears to be present up to 24 months' corrected age. There is some evidence at 3 months that interventions with specific motor components are most effective.

Item Type: Journal Article
Additional Information: This is the accepted version of an article accepted for publication in Pediatrics. The definitive publisher-authenticated version is available from:
Keywords: Premature infants, Motor skills, Intervention
Faculty: ARCHIVED Faculty of Health, Social Care & Education (until September 2018)
Depositing User: Professor S Redsell
Date Deposited: 28 Sep 2016 06:45
Last Modified: 09 Sep 2021 18:59

Actions (login required)

Edit Item Edit Item