Temporal reproduction and its neuroanatomical correlates in adults with attention deficit hyperactivity disorder and their unaffected first-degree relatives

Pironti, Valentino A. and Lai, Meng-Chuan and Morein-Zamir, Sharon and Müller, Ulrich and Bullmore, Edward T. and Sahakian, Barbara J. (2016) Temporal reproduction and its neuroanatomical correlates in adults with attention deficit hyperactivity disorder and their unaffected first-degree relatives. Psychological Medicine, 46 (12). pp. 2561-2569. ISSN 1469-8978

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Official URL: http://doi.org/10.1017/S003329171600101X

Abstract

Background: Little is known about time perception, its putative role as cognitive endophenotype, and its neuroanatomical underpinnings in adults with attention deficit hyperactivity disorder (ADHD). Method: Twenty adults with ADHD, 20 unaffected first-degree relatives and 20 typically developing controls matched for age and gender undertook structural magnetic resonance imaging scans. Voxel-based morphometry with DARTEL was performed to obtain regional grey-matter volumes. Temporal processing was investigated as a putative cognitive endophenotype using a temporal reproduction paradigm. General linear modelling was employed to examine the relationship between temporal reproduction performances and grey-matter volumes. Results: ADHD participants were impaired in temporal reproduction and unaffected first-degree relatives performed in between their ADHD probands and typically developing controls. Increased grey-matter volume in the cerebellum was associated with poorer temporal reproduction performance. Conclusions: Adults with ADHD are impaired in time reproduction. Performances of the unaffected first-degree relatives are in between ADHD relatives and controls, suggesting that time reproduction might be a cognitive endophenotype for adult ADHD. The cerebellum is involved in time reproduction and might play a role in driving time performances.

Item Type: Journal Article
Keywords: adhd
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Sharon Morein
Date Deposited: 02 Aug 2016 14:58
Last Modified: 14 Nov 2019 16:11
URI: http://arro.anglia.ac.uk/id/eprint/700548

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