Modified platelet deposition on matrix metalloproteinase 13 digested collagen I

Howes, Joanna-Marie and Pugh, Nicholas and Knäuper, Vera and Farndale, Richard W. (2015) Modified platelet deposition on matrix metalloproteinase 13 digested collagen I. Journal of Thrombosis and Haemostasis, 13 (12). pp. 2253-2259. ISSN 1538-7836

[img]
Preview
Text
Published Version
Available under the following license: Creative Commons Attribution.

Download (1MB) | Preview
Official URL: https://doi.org/10.1111/jth.13166

Abstract

Atherothrombosis underlies acute coronary syndromes, including unstable angina and acute myocardial infarction. Within the unstable plaque, monocytes express collagenolytic matrix metalloproteinases (MMPs) including MMP-13 which degrades fibrous collagen. Following rupture, vessel wall components including degraded collagen are exposed to circulating platelets. Platelet receptors then mediate the recruitment and activation of platelets to form a thrombus, blocking blood flow and resulting in myocardial infarction and sudden death.

Item Type: Journal Article
Keywords: collagen, collagenase, platelets, GPVI collagen receptor, matrix metalloproteinase 13
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Repository Admin
Date Deposited: 23 Dec 2015 10:50
Last Modified: 09 Sep 2021 19:00
URI: https://arro.anglia.ac.uk/id/eprint/592532

Actions (login required)

Edit Item Edit Item