nutrients-07-02044 (2).pdf (479.45 kB)
Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?
journal contribution
posted on 2023-07-26, 13:42 authored by Pierre-Olivier Lang, Richard AspinallVitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its extra-skeletal roles. It has an important influence on the body's immune system and modulates both innate and adaptive immunity and regulates the inflammatory cascade. In this review our aim was to describe how VitD might influence immune responsiveness and its potential modulating role in vaccine immunogenicity. In the first instance, we consider the literature that may provide molecular and genetic support to the idea that VitD status may be related to innate and/or adaptive immune response with a particular focus on vaccine immunogenicity and then discuss observational studies and controlled trials of VitD supplementation conducted in humans. Finally, we conclude with some knowledge gaps surrounding VitD and vaccine response, and that it is still premature to recommend "booster" of VitD at vaccination time to enhance vaccine response.
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Refereed
- Yes
Volume
7Issue number
3Page range
2044-2060Publication title
NutrientsISSN
2072-6643External DOI
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MDPIFile version
- Published version
Language
- eng
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Legacy posted date
2015-12-18Legacy creation date
2017-11-27Legacy Faculty/School/Department
ARCHIVED Faculty of Medical Science (until September 2018)Usage metrics
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