Agouti signalling protein is an inverse agonist to the wildtype and agonist to the melanic variant of the melanocortin 1 receptor in the grey squirrel S (3).pdf (1.39 MB)
Agouti signalling protein is an inverse agonist to the wildtype and agonist to the melanic variant of the melanocortin-1 receptor in the grey squirrel (Sciurus carolinensis)
journal contribution
posted on 2023-08-30, 14:05 authored by Helen R. McRobie, Linda M. King, Cristina Fanutti, Martyn F. Symmons, Peter J. CoussonsThe melanocortin-1 receptor (MC1R) is a key regulator of mammalian pigmentation. Melanism in the grey squirrel is associated with an eight amino acid deletion in the mutant melanocortin-1 receptor with 24 base pair deletion (MC1RΔ24) variant. We demonstrate that the MC1RΔ24 exhibits a higher basal activity than the wildtype MC1R (MC1R-wt). We demonstrate that agouti signalling protein (ASIP) is an inverse agonist to the MC1R-wt but is an agonist to the MC1RΔ24. We conclude that the deletion in the MC1RΔ24 leads to a receptor with a high basal activity which is further activated by ASIP. This is the first report of ASIP acting as an agonist to MC1R.
History
Refereed
- Yes
Volume
588Issue number
14Page range
2335-2343Publication title
FEBS LettersISSN
1873-3468External DOI
Publisher
WileyFile version
- Accepted version
Language
- eng
Official URL
Legacy posted date
2015-03-11Legacy creation date
2020-07-02Legacy Faculty/School/Department
ARCHIVED Faculty of Science & Technology (until September 2018)Usage metrics
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