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Acute burn induced coagulopathy
journal contribution
posted on 2023-07-26, 13:29 authored by Michael Parker, Peter B. Sherren, Joseph Hussey, Rebecca V. Martin, Tapiwa Kundishora, Bruce EmersonBackground:
Acute traumatic coagulopathy is well described in the trauma population. Major burns are characterised by a similar endothelial injury and cellular hypoperfusion. These features could be a driver for an acute burn induced coagulopathy (ABIC).
Methods:
Patients admitted to a regional burn centre over a 71 months period with a total body surface area burn of 30% or more were identified. The metavision electronic patient database was scrutinised for a predetermined list of demographics, interventions and admission investigations to identify any clinically significant ABIC.
Results:
On admission 39.3% of the 117 patients analysed met our criteria for a coagulopathy. Of the patients with a coagulopathy, 71.7% had an elevated Prothrombin Time (PT), 2.2% had an elevated Activated Partial Thromboplastin time (APPT) and 26.1% had an elevation of both. Patients with a coagulopathy received a similar volume of fluid (p = 0.08). There was a statistically significant correlation between the PT and the abbreviated burn severity index (p = 0.0013, r = 0.292) and serum lactate (p = 0.0013, r = 0.292). ABIC was an independent predictor of 28 day mortality, OR 3.42(1.11–10.56).
Conclusion:
In patients with major thermal injuries a clinically significant ABIC exists. Early diagnosis and treatment of ABIC should be considered particularly in those undergoing total burn wound excision.
History
Refereed
- Yes
Volume
39Issue number
6Page range
1157-1161Publication title
Burns: Journal of the International Society for Burn InjuriesISSN
1879-1409External DOI
Publisher
ElsevierLanguage
- other
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Legacy posted date
2013-11-29Legacy Faculty/School/Department
ARCHIVED Faculty of Health, Social Care & Education (until September 2018)Usage metrics
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