Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation

Docquier, France and Kita, Georgia-Xanthi and Farrar, Dawn and Jat, Parmjit and O'Hare, Michael and Chernukhin, Igor and Gretton, Svetlana and Mandal, Adhip and Alldridge, Louise and Klenova, Elena (2009) Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation. Clinical Cancer Research, 15 (18). pp. 5762-5771. ISSN 1557-3265

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1158/1078-0432.CCR-09-0329

Abstract

There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180), modified by poly(ADP-ribosyl)ation. This study was aimed to investigate differential poly(ADP-ribosyl)ation of CTCF in normal and tumor breast tissues.

Item Type: Journal Article
Faculty: ARCHIVED Faculty of Health, Social Care & Education (until September 2018)
Depositing User: Repository Admin
Date Deposited: 20 Sep 2011 11:49
Last Modified: 10 May 2021 16:30
URI: https://arro.anglia.ac.uk/id/eprint/142723

Actions (login required)

Edit Item Edit Item