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Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation
journal contribution
posted on 2023-07-26, 12:49 authored by France Docquier, Georgia-Xanthi Kita, Dawn Farrar, Parmjit Jat, Michael O'Hare, Igor Chernukhin, Svetlana Gretton, Adhip Mandal, Louise Alldridge, Elena KlenovaThere is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180), modified by poly(ADP-ribosyl)ation. This study was aimed to investigate differential poly(ADP-ribosyl)ation of CTCF in normal and tumor breast tissues.
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Refereed
- Yes
Volume
15Issue number
18Page range
5762-5771Publication title
Clinical Cancer ResearchISSN
1557-3265External DOI
Publisher
American Association for Cancer ResearchLanguage
- other
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2011-09-20Legacy Faculty/School/Department
ARCHIVED Faculty of Health, Social Care & Education (until September 2018)Usage metrics
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