Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis

Pizzol, Damiano and Demurtas, Jacopo and Stubbs, Brendon and Soysal, Pinar and Mason, Corina and Isik, Ahmet T. and Solmi, Marco and Smith, Lee and Veronese, Nicola (2019) Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis. American Journal of Men's Health. ISSN 1557-9891 (Accepted)

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Abstract

Globally, there is increasing usage and legalization of cannabis. In addition to its reported thera-peutic effects, cannabis has several health risks which are not clearly defined. Erectile dysfunction (ED) is the most common male sexual disorder and there are plausible mechanisms linking canna-bis use to ED. No attempt has been made to collate the literature on this topic. The aim of this re-view was to summarize the prevalence and risk of ED in cannabis users compared to controls. A systematic review of major databases from inception to 16/01/2019, without language re-striction, was undertaken to identify studies investigating cannabis use and presence of ED. The analysis compared the prevalence of ED in cannabis users versus controls. Consequently was cal-culated the odds ratio (OR) with 95% confidence intervals (CI), applying a random-effect model. Were included five case-control studies with data from 3,395 healthy men, 1,035 using cannabis (smoking) and 2,360 non-users. The overall prevalence of ED in cannabis users was 69.1% (95% CI: 38.0-89.1), whilst the correspondent figure in controls was 34.7% (95% CI: 20.3-52.7). The odds of ED in cannabis users was almost four times that of controls (OR=3.83; 95%CI: 1.30-11.28; p=0.02), even if characterized by high heterogeneity (I2=90%) and the prediction intervals overlapped 1.00 (95% CI: 0.35-7.26). Data suggest that ED is twice as high in cannabis users compared to controls. Future longitudinal research is needed to confirm/refute this and explore if a dose response relationship between cannabis and ED may be evident.

Item Type: Journal Article
Keywords: Cannabis, Erectile dysfunction, Prevalence, Meta-analysis, Systematic review
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 06 Nov 2019 16:20
Last Modified: 14 Nov 2019 16:07
URI: http://arro.anglia.ac.uk/id/eprint/704928

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