Prospective associations of cardiovascular disease with physical performance and disability: a longitudinal cohort study in the Osteoarthritis Initiative

Veronese, Nicola and Stubbs, Brendon and Jackson, Sarah E. and Koyanagi, Ai and Noventa, Vania and Bolzetta, Francesco and Cester, Alberto and Soysal, Pinar and Maggi, Stefania and López Sánchez, Guillermo F. and Loosemore, Mike and Demurtas, Jacopo and Smith, Lee (2019) Prospective associations of cardiovascular disease with physical performance and disability: a longitudinal cohort study in the Osteoarthritis Initiative. Wiener Klinische Wochenschrift: The Central European Journal of Medicine. ISSN 1613-7671

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Official URL: https://doi.org/10.1007/s00508-019-01567-y

Abstract

Background: Literature regarding cardiovascular disease (CVD) and incident physical performance limitations/disability in older people is equivocal. Aims: We aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations/disability in a large population-based sample. Methods: It was an eight-year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed)/disability score were analyzed using generalized linear models with repeated measures. Results: The analyzed sample comprised 4,796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8-year follow-up period than those without CVD (p=0.006). Conclusions: In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8-year follow-up period than those without CVD. However, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.

Item Type: Journal Article
Keywords: Cardiovascular disease, Disability, Osteoarthritis, Physical Performance
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 08 Oct 2019 10:04
Last Modified: 14 Nov 2019 16:07
URI: http://arro.anglia.ac.uk/id/eprint/704842

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