Prevention of Postdental Procedure Bacteremia: A Network Meta-analysis

Zeng, B. S. and Lin, S. Y. and Tu, Yu-Kang and Wu, Yi-Cheng and Stubbs, Brendon and Liang, Chih-Sung and Yeh, Ta-Chuan and Chen, Tien-Yu and Carvalho, Andre F. and Lin, Pao-Yen and Lei, Wei‐Te and Hsu, Chih‐Wei and Chen, Yen-Wen and Tseng, Ping-Tao and Chen, Chang-Hua (2019) Prevention of Postdental Procedure Bacteremia: A Network Meta-analysis. Journal of Dental Research, 98 (11). pp. 1204-1210. ISSN 1544-0591

[img] Text
Accepted Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (119kB)
[img] Slideshow (Supplementary Files (PowerPoint))
Accepted Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (2MB)
Official URL: https://doi.org/10.1177/0022034519870466

Abstract

Postdental procedure bacteremia is common and troublesome. The comparative efficacy of multiple prophylactic interventions is unclear. We compared the efficacy of interventions for the prevention of postdental procedure bacteremia. We conducted a review of ClinicalKey, Cochrane CENTRAL, Embase, ProQuest, PubMed, ScienceDirect, Web of Science, and ClinicalTrials.gov from inception to December 4, 2018. Randomized controlled trials that evaluated prophylactic interventions for the prevention of postdental procedure bacteremia were eligible. The primary outcome was the incidence of postdental procedure bacteremia. A total of 24 trials were included with 2,147 participants. Our network meta-analysis demonstrated that intravenous administration of 1,000/200 mg of amoxicillin/clavulanate provided the least incidence of postdental procedure bacteremia among all the prophylactic interventions (odds ratio = 0.03, 95% CI = 0.00 to 0.63) as compared with the placebo/controls. Oral 3 g of amoxicillin had the least incidence of postdental procedure bacteremia among all oral or topical forms of prophylactic interventions (odds ratio = 0.10, 95% CI = 0.02 to 0.44) as compared with the placebo/controls. No serious adverse events, such as anaphylactic shock, mortality, and the development of antibiotic-resistant bacteria, were reported. None of the included subjects were of high risk of infectious endocarditis. Our network meta-analysis demonstrates that intravenous amoxicillin/clavulanate and oral amoxicillin might be the best prophylactic interventions in preventing postdental procedure bacteremia among all the oral/topical forms of interventions for the overall populations.

Item Type: Journal Article
Keywords: prophylaxis, dental procedure, randomized controlled tria, antibiotics, antimicrobial, intervention
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Ian Walker
Date Deposited: 27 Sep 2019 07:50
Last Modified: 14 Nov 2019 16:07
URI: http://arro.anglia.ac.uk/id/eprint/704824

Actions (login required)

Edit Item Edit Item