Experimental models of corneal endothelial cell therapy and translational challenges to clinical practice

Rolev, Kostadin D. and Coussons, Peter J. and King, Linda M. and Rajan, Madhavan S. (2019) Experimental models of corneal endothelial cell therapy and translational challenges to clinical practice. Experimental Eye Research, 188. p. 107794. ISSN 1096-0007

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Official URL: https://doi.org/10.1016/j.exer.2019.107794

Abstract

The human corneal endothelium (CE) is a post-mitotic monolayer of endothelial cells, thought to be incapable of in vivo regeneration. Dysfunction of the CE is a commonly cited indication for corneal transplantation, with corneal blindness being the fifth most common cause of blindness globally. In 2012 alone 184,576 corneal transplants were performed in 116 countries (Gain et al., 2016). Presently, outcomes following human corneal transplantation have been reported to have over 97% success rate in restoring the recipient's vision (Patel et al., 2019). However, the continuing demand for cadaveric human corneas has driven research into alternative sources of CE and with the advent of protocols to produce cultured hCECs there is now the potential for cell therapy to regenerate the damaged CE. This review aims to examine the merits and limitations of different types of human and animal models used so far to test the concept of CE cell therapy.

Item Type: Journal Article
Keywords: Corneal endothelium, Cell therapy, Corneal endothelial cell transplantation, Fuchs corneal dystrophy
Faculty: Faculty of Science & Engineering
Depositing User: Lisa Blanshard
Date Deposited: 19 Sep 2019 10:20
Last Modified: 14 Nov 2019 16:07
URI: http://arro.anglia.ac.uk/id/eprint/704772

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