The Activation Status of the TGF-β Transducer Smad2 is Associated with a Reduced Survival in Gastrointestinal Cancers: a Systematic Review and Meta-Analysis

Girolami, Ilaria and Veronese, Nicola and Smith, Lee and Caruso, Maria Gabriella and Reddavide, Rosa and Leandro, Gioacchino and Demurtas, Jacopo and Nottegar, Alessia (2019) The Activation Status of the TGF-β Transducer Smad2 is Associated with a Reduced Survival in Gastrointestinal Cancers: a Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 20 (15). p. 3831. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms20153831

Abstract

Aberrant function of Smad2, a crucial member of the transforming growth factor beta (TGF-β) signalling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05–2.37, p = 0.029, I2 = 84%), also after having adjusted for potential confounders (RR, 1.65; 95% CI, 1.24–2.18; p < 0.001; I2 = 4%). This finding highlights the importance of the TGF-β signaling in this type of cancers. In this line, further studies are needed to explore more in depth this important molecular pathway, focusing also on potential therapeutic strategies based on its effectors or molecular targets.

Item Type: Journal Article
Keywords: Smad2, TGF-β, pSmad2, phosphorylation, signaling
Faculty: Faculty of Science & Engineering
Depositing User: Lee Smith
Date Deposited: 02 Aug 2019 09:40
Last Modified: 14 Nov 2019 16:07
URI: http://arro.anglia.ac.uk/id/eprint/704607

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