Pathophysiology and Future Therapeutic Perspectives for Resolving Fibrosis in Peyronie’s Disease

Milenkovic, Uros and Ilg, Marcus M. and Cellek, Selim and Albersen, Maarten (2019) Pathophysiology and Future Therapeutic Perspectives for Resolving Fibrosis in Peyronie’s Disease. Sexual Medicine Reviews. ISSN 2050-0521

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Official URL: https://doi.org/10.1016/j.sxmr.2019.02.004

Abstract

Peyronie’s disease (PD) is a debilitating affliction for the male population, causing severe curvatures to the erect penis and erectile dysfunction in about 50% of men. This deviation of the penis significantly impairs sexual intercourse and causes depression and strains in the relationship. As of today, medical treatment options are far and few between, with surgery remaining as the sole reliable treatment. In this review, a general overview regarding fibrosis and the specific role of extracellular matrix, macrophages and myofibroblasts in PD will be given. Additionally, we will provide an overview of past and present research and how this has shaped our vision concerning the pathophysiology of PD. Using this knowledge, we will attempt to provide future directions for PD research and drug discovery, which is urgently needed, since its treatment has essentially been stagnating for about 30 years.

Item Type: Journal Article
Keywords: Peyronie's Disease, Fibrosis, Pathophysiology, RNA Sequencing, Drug Discovery, Phenotypical Screening
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Ian Walker
Date Deposited: 12 Apr 2019 15:53
Last Modified: 14 Nov 2019 16:08
URI: http://arro.anglia.ac.uk/id/eprint/704278

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