The relationship between dietary vitamin K and depressive symptoms in late adulthood: a cross-sectional analysis from a large cohort study

Bolzetta, Francesco and Veronese, Nicola and Stubbs, Brendon and Noale, Marianna and Vaona, Alberto and Demurtas, Jacopo and Celotto, Stefano and Cacco, Chiara and Cester, Alberto and Caruso, Maria G. and Reddavide, Rosa and Notarnicola, Maria and Maggi, Stefania and Koyanagi, Ai and Fornaro, Michele and Firth, Joseph and Smith, Lee and Solmi, Marco (2019) The relationship between dietary vitamin K and depressive symptoms in late adulthood: a cross-sectional analysis from a large cohort study. Nutrients, 11 (4). p. 787. ISSN 2072-6643

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Official URL: https://doi.org/10.3390/nu11040787

Abstract

Few studies assessed associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants aged 45-79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) > 16. To investigate associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, adjusting for potential confounders. Overall 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR=0.58; 95%CI: 0.43-0.80). This effect was present only in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association.

Item Type: Journal Article
Keywords: vitamin K, depression, osteoarthritis initiative, mental health, diet, nutrition
Faculty: Faculty of Science & Engineering
Depositing User: Lee Smith
Date Deposited: 01 Apr 2019 12:00
Last Modified: 14 Nov 2019 16:08
URI: http://arro.anglia.ac.uk/id/eprint/704216

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