Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?

Viceconti, Marco and Qasim, Muhammad and Bhattacharya, Pinaki and Li, Xinshan (2018) Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful? Current Osteoporosis Reports, 16 (3). pp. 216-223. ISSN 1544-2241

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Official URL: http://dx.doi.org/10.1007/s11914-018-0438-8

Abstract

Purpose of Review: This study reviews the available literature to compare the accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) and of subject-specific finite element models derived from quantitative computed tomography (QCT-SSFE) in predicting bone strength measured experimentally on cadaver bones, as well as their clinical accuracy both in terms of discrimination and prediction. Based on this information, some basic cost-effectiveness calculations are performed to explore the use of QCT-SSFE instead of DXA-aBMD in (a) clinical studies with femoral strength as endpoint, (b) predictor of the risk of hip fracture in low bone mass patients. Recent Findings: Recent improvements involving the use of smooth-boundary meshes, better anatomical referencing for proximal-only scans, multiple side-fall directions, and refined boundary conditions increase the predictive accuracy of QCT-SSFE. Summary: If these improvements are adopted, QCT-SSFE is always preferable over DXA-aBMD in clinical studies with femoral strength as the endpoint, while it is not yet cost-effective as a hip fracture risk predictor, although pathways that combine both QCT-SSFE and DXA-aBMD are promising.

Item Type: Journal Article
Keywords: Hip fracture, Subject-specific finite element models, Cost-benefit, Quanitative computed-tomography, Proximal femur, Postmenopausal women, In-vitro, Mineral density, Risk, Men, Osteoporosis, Association
Faculty: Faculty of Science & Technology
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 27 Mar 2019 15:04
Last Modified: 27 Mar 2019 15:04
URI: http://arro.anglia.ac.uk/id/eprint/704212

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