Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies

Smith, Lee and Luchini, Claudio and Demurtas, Jacopo and Soysal, Pinar and Stubbs, Brendon and Hamer, Mark and Nottegar, Alessia and Lawlor, Rita T. and López Sánchez, Guillermo F. and Firth, Joseph and Koyanagi, Ai and Roberts, Justin D. and Willeit, Peter and Waldhoer, Thomas and Loosemore, Mike and Abbs, Adam D. and Johnstone, James and Yang, Lin and Veronese, Nicola (2019) Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies. Ageing Research Reviews, 51. pp. 1-10. ISSN 1872-9649

[img] Text
Accepted Version
Restricted to Repository staff only until 15 February 2020.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (249kB) | Request a copy
Official URL: https://doi.org/10.1016/j.arr.2019.02.003

Abstract

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. To evaluate the credibility of the identified evidence, we assessed also heterogeneity, evidence for small-study effect and evidence for excess significance bias. Twenty-one relevant meta-analyses were identified reporting on 50 different outcomes and including a total of 326 observational studies. The level of evidence was high only for the association of short telomeres with higher risk of gastric cancer in the general population (relative risk, RR=1.95, 95%CI: 1.68-2.26), and moderate for the association of shorter telomeres with diabetes or with Alzheimer’s disease, even if limited to meta-analyses of case-control studies. There was weak evidence for twenty outcomes and not significant association for 27 health outcomes. The present umbrella review demonstrates that shorter telomere length may have an important role in incidence gastric cancer and, probably, diabetes and Alzheimer’s disease. At the same time, conversely to general assumptions, it does not find strong evidence supporting the notion that shorter telomere length plays an important role in many health outcomes that have been studied thus far.

Item Type: Journal Article
Keywords: telomere length, health outcomes, umbrella review
Faculty: Faculty of Science & Engineering
Depositing User: Lee Smith
Date Deposited: 14 Feb 2019 12:39
Last Modified: 14 Nov 2019 16:08
URI: http://arro.anglia.ac.uk/id/eprint/704113

Actions (login required)

Edit Item Edit Item