European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism

Pristipino, Christian and Sievert, Horst and D’Ascenzo, Fabrizio and Louis Mas, Jean and Meier, Bernhard and Scacciatella, Paolo and Hildick-Smith, David and Gaita, Fiorenzo and Toni, Danilo and Kyrle, Paul and Thomson, John and Derumeaux, Genevieve and Onorato, Eustaquio and Sibbing, Dirk and Germonpré, Peter and Berti, Sergio and Chessa, Massimo and Bedogni, Francesco and Dudek, Dariusz and Hornung, Marius and Zamorano, Jose and D’Ascenzo, Fabrizio and Omedè, Pierluigi and Ballocca, Flavia and Barbero, Umberto and Giordana, Francesca and Gili, Sebastiano and Iannaccone, Mario and Capodannno, Davide and Valgimigli, Marco and Byrne, Robert and Akagi, Teiji and Carroll, John and Dalvi, Bharat and Ge, Junbo and Kasner, Scott and Michel-Behnke, Ina and Pedra, Carlos and Rhodes, John and Søndergaard, Lars and Thomassen, Lars and Biondi-Zoccai, Giuseppe G. L. (2018) European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism. European Heart Journal. ISSN 1522-9645

Full text not available from this repository.
Official URL: https://doi.org/10.1093/eurheartj/ehy649

Abstract

The presence of a patent foramen ovale (PFO) is implicated in the pathogenesis of a number of medical conditions; however, the subject remains controversial and no official statements have been published. This interdisciplinary paper, prepared with involvement of eight European scientific societies, aims to review the available trial evidence and to define the principles needed to guide decision making in patients with PFO. In order to guarantee a strict process, position statements were developed with the use of a modified grading of recommendations assessment, development, and evaluation (GRADE) methodology. A critical qualitative and quantitative evaluation of diagnostic and therapeutic procedures was performed, including assessment of the risk/benefit ratio. The level of evidence and the strength of the position statements of particular management options were weighed and graded according to predefined scales. Despite being based often on limited and non-randomised data, while waiting for more conclusive evidence, it was possible to conclude on a number of position statements regarding a rational general approach to PFO management and to specific considerations regarding left circulation thromboembolism. For some therapeutic aspects, it was possible to express stricter position statements based on randomised trials. This position paper provides the first largely shared, interdisciplinary approach for a rational PFO management based on the best available evidence.

Item Type: Journal Article
Keywords: thromboembolism, patent foramen ovale
Faculty: Faculty of Medical Science
Depositing User: Lisa Blanshard
Date Deposited: 13 Nov 2018 16:19
Last Modified: 13 Nov 2018 16:19
URI: http://arro.anglia.ac.uk/id/eprint/703835

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