Association between gait speed with mortality, cardiovascular disease and cancer: a systematic review and meta-analysis of prospective cohort studies

Veronese, Nicola and Stubbs, Brendon and Volpato, Stefano and Zuliani, Giovanni and Maggi, Stefania and Cesari, Matteo and Lipnicki, Darren and Smith, Lee and Schofield, Patricia and Firth, Joseph and Vancampfort, Davy and Koyanagi, Ai and Pilotto, Alberto and Cereda, Emanuele (2018) Association between gait speed with mortality, cardiovascular disease and cancer: a systematic review and meta-analysis of prospective cohort studies. Journal of the American Medical Directors Association, 19 (11). 981-988.e7. ISSN 1538-9375

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Official URL: https://doi.org/10.1016/j.jamda.2018.06.007

Abstract

Objectives: Slow gait speed may be associated with premature mortality, cardiovascular disease (CVD) and cancer, although a comprehensive meta-analysis is lacking. In this systematic review and meta-analysis, we explored potential associations between gait speed and mortality, incident CVD and cancer. Design: A systematic search in major databases was undertaken from inception until March 15th 2018 for prospective cohort studies reporting data on gait speed and mortality, incident CVD and cancer. Setting and Participants: all available. Measures: The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs), based on the model with the maximum number of covariates for each study between gait speed (categorized as decrease in 0.1 m/s) and mortality, incident CVD and cancer were meta-analysed with a random-effects model. Results: Among 7,026 papers, 44 articles corresponding to 48 independent cohorts were eligible. The studies followed-up a total of 101,945 participants (mean age 72.2 years; 55% women) for a median of 5.4 years. After adjusting for a median of 9 potential confounders and the presence of publication bias, each reduction of 0.1 m/s in gait speed was associated with a 14% increased risk of earlier mortality (45 studies; HR=1.12; 95% CI: 1.09-1.14; I2=90%) and 8% increased risk of CVD (13 studies; HR=1.08; 95%CI: 1.03-1.13; I2=81%), but no relationship with cancer was observed (HR=1.00; 95%CI: 0.97-1.04; I2=15%). Conclusion/implications: Slow gait speed may be a predictor of mortality and CVD in older adults. Since gait speed is a quick and inexpensive measure to obtain our study suggests that it should be routinely used and may help identify people at risk of premature mortality and CVD.

Item Type: Journal Article
Keywords: Gait speed, mortality, cardiovascular disease, cancer, meta-analysis
Faculty: ARCHIVED Faculty of Science & Technology (until September 2018)
Depositing User: Lee Smith
Date Deposited: 08 Jun 2018 08:41
Last Modified: 14 Nov 2019 16:08
URI: http://arro.anglia.ac.uk/id/eprint/703099

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