Hand grip strength and cognitive function among elderly cancer survivors

Yang, Lin and Koyanagi, Ai and Smith, Lee and Hu, Liang and Colditz, Graham and Toriola, Adetunji and López Sánchez, Guillermo Felipe and Vancampfort, Davy and Hamer, Mark and Stubbs, Brendon and Waldhor, Thomas (2018) Hand grip strength and cognitive function among elderly cancer survivors. PLOS ONE, 13 (6). e0197909. ISSN 1932-6203

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Official URL: http://dx.doi.org/10.1371/journal.pone.0197909

Abstract

Background: We evaluated the associations of handgrip strength and cognitive function in cancer survivors ≥ 60 years old using data from the National Health and Nutrition Examination Survey (NHANES). Methods: Data in two waves of NHANES (2011-2014) were aggregated. Handgrip strength in kilogram (kg) was defined as the maximum value achieved using either hand. Two cognitive function tests were conducted among adults 60 years and older. The Animal Fluency Test (AFT) examines categorical verbal fluency (a component of executive function), and the Digital Symbol Substitution test (DSST) assesses processing speed, sustained attention, and working memory. Survey analysis procedures were used to account for the complex sampling design of the NHANES. Multiple linear regression models were used to estimate associations of handgrip strength with cognitive test scores, adjusting for confounders (age, gender, race/ethnicity, education, marital status, smoking status, depressive symptoms and leisure time physical activity). Results: Among 383 cancer survivors (58.5% women, mean age=70.9 years, mean BMI=29.3 kg/m2), prevalent cancer types were breast (22.9%), prostate (16.4%), colon (6.9%) and cervix (6.2%). In women, each increase in kg of handgrip strength was associated with 0.20 (95% CI: 0.08 to 0.33) higher score on AFT and 0.83 (95% CI: 0.30 to 1.35) higher score on DSST. In men, we observed an inverted U-shape association where cognitive function peaked at handgrip strength of 40-42 kg. Conclusions: Handgrip strength, a modifiable factor, appears to be associated with aspects of cognitive functions in cancer survivors. Prospective studies are needed to address their causal relationship.

Item Type: Journal Article
Keywords: Cancer Survivor, Grip Strength, Cognition
Faculty: Faculty of Science & Technology
Depositing User: Lee Smith
Date Deposited: 15 May 2018 13:50
Last Modified: 02 Nov 2018 10:59
URI: http://arro.anglia.ac.uk/id/eprint/703012

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