The Relationship Between the Dietary Inflammatory Index and Incident Frailty: A Longitudinal Cohort Study

Shivappa, Nitin and Stubbs, Brendon and Hébert, James R. and Cesari, Matteo and Schofield, Patricia and Soysal, Pinar and Maggi, Stefania and Veronese, Nicola (2018) The Relationship Between the Dietary Inflammatory Index and Incident Frailty: A Longitudinal Cohort Study. Journal of the American Medical Directors Association, 19 (1). pp. 77-82. ISSN 1538-9375

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Official URL: https://doi.org/10.1016/j.jamda.2017.08.006

Abstract

Objective: Inflammation is key risk factor for several conditions in the elderly. However, the relationship between inflammation and frailty is still unclear. We investigated whether higher dietary inflammatory index (DII) scores were associated with higher incidence of frailty in a cohort of North Americans. Design: Longitudinal, with a follow-up of 8 years. Setting: Osteoarthritis Initiative. Participants: A total of 4421 participants with, or at high risk of, knee osteoarthritis. Measurements: DII scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and categorized into sex-specific quartiles. Frailty was defined as 2 out of 3 of the criteria of the Study of Osteoporotic Fracture study (ie, weight loss, inability to rise from a chair 5 times, and poor energy). The strength of the association between baseline DII score and incident frailty was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios. Results: A total of 4421 community-dwelling participants (2564 female participants; mean age: 61.3 years) without frailty at baseline were identified from the Osteoarthritis Initiative. During 8 years of follow-up, 356 individuals developed frailty (8.2%). Using Cox's regression analysis, adjusting for 11 potential confounders, participants with the highest DII score (quartile 4) had a significantly higher risk of experiencing frailty (hazard ratio 1.37; 95% confidence interval 1.01–1.89; P = .04) compared with participants with the lowest DII score (quartile 1). The association between DII score and frailty was significant only in men. Conclusions: Higher DII scores, indicating a more proinflammatory diet, are associated with higher incidence of frailty, particularly in men.

Item Type: Journal Article
Keywords: Aged, Dietary inflammatory index, Frailty, Inflammation
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Brendon Stubbs
Date Deposited: 10 Oct 2017 12:45
Last Modified: 24 Apr 2019 08:24
URI: http://arro.anglia.ac.uk/id/eprint/702264

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