Low-Dose Aspirin Use and Cognitive Function in Older Age: A Systematic Review and Meta-analysis

Veronese, Nicola and Stubbs, Brendon and Maggi, Stefania and Thompson, Trevor and Schofield, Patricia and Muller, Christoph and Tseng, Ping-Tao and Lin, Pao-Yen and Carvalho, Andre F. and Solmi, Marco (2017) Low-Dose Aspirin Use and Cognitive Function in Older Age: A Systematic Review and Meta-analysis. Journal of the American Geriatrics Society, 65 (8). pp. 1763-1768. ISSN 1532-5415

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Official URL: http://dx.doi.org/10.1111/jgs.14883

Abstract

Objectives: To investigate whether low-dose aspirin (<300 mg/d) can influence the onset of cognitive impairment or dementia in observational studies and improve cognitive test scores in randomized controlled trials (RCTs) in participants without dementia. Design: Systematic review and meta-analysis. Setting: Observational and interventional studies. Participants: Individuals with no dementia or cognitive impairment initially. Measurements: Odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for the maximum number of covariates from each study, were used to summarize data on the incidence of dementia and cognitive impairment in observational studies. Standardized mean differences (SMDs) were used for cognitive test scores in RCTs. Results: Of 2,341 potentially eligible articles, eight studies were included and provided data for 36,196 participants without dementia or cognitive impairment at baseline (mean age 66, 63% female). After adjusting for a median of three potential confounders over a median follow-up period of 6 years, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment (5 studies, N = 26,159; OR = 0.82, 95% CI = 0.55–1.22, P = .33, I2 = 67%). In three RCTs (N = 10,037; median follow-up 5 years), the use of low-dose aspirin was not associated with significantly better global cognition (SMD=0.005, 95% CI=–0.04–0.05, P = .84, I2 = 0%) in individuals without dementia. Adherence was lower in participants taking aspirin than in controls, and the incidence of adverse events was higher. Conclusion: This review found no evidence that low-dose aspirin buffers against cognitive decline or dementia or improves cognitive test scores in RCTs.

Item Type: Journal Article
Additional Information: This is the peer reviewed version, which has been published in final form at: http://dx.doi.org/10.1111/jgs.14883. This article may be used for non-commercial purposes in accordance with Wiley's terms and conditions for self-archiving.
Keywords: Aspirin, Cognition
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Brendon Stubbs
Date Deposited: 24 Apr 2017 09:01
Last Modified: 05 Feb 2019 09:59
URI: http://arro.anglia.ac.uk/id/eprint/701704

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