Biomarkers associated with sedentary behaviour in older adults: A systematic review

Wirth, Katharina and Klenk, Jochen and Brefka, Simone and Dallmeier, Dhayana and Faehling, Kathrin and i Figuls, Marta R. and Tully, Mark A. and Giné-Garriga, Maria and Caserotti, Paolo and Salvà, Antoni and Rothenbacher, Dietrich and Denkinger, Michael and Stubbs, Brendon and SITLESS consortium, (2017) Biomarkers associated with sedentary behaviour in older adults: A systematic review. Ageing Research Reviews, 35. pp. 87-111. ISSN 1872-9649

[img]
Preview
Text
Published Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview
[img] Other (Acceptance)
Other
Restricted to Repository staff only

Download (133kB)
Official URL: http://dx.doi.org/10.1016/j.arr.2016.12.002

Abstract

OBJECTIVE: Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. METHODS: Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60years and accelerometer wear time ≥3days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731). RESULTS: 12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n=15), waist circumference (WC, n=15), blood pressure (n=11), triglycerides (n=12) and high density lipoprotein (HDL, n=15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL. CONCLUSION: Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.

Item Type: Journal Article
Keywords: Older adults, Sedentary behaviour, Biomarker
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Brendon Stubbs
Date Deposited: 14 Mar 2017 09:40
Last Modified: 07 Jan 2019 12:07
URI: http://arro.anglia.ac.uk/id/eprint/701551

Actions (login required)

Edit Item Edit Item