Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis

Veronese, Nicola and Sergi, Giuseppe and Stubbs, Brendon and Bourdel-Marchasson, Isabelle and Tessier, Daniel and Sieber, C. and Strandberg, Timo and Gillain, S. and Barbagallo, Mario and Crepaldi, Gaetano and Maggi, Stefania and Manzato, Enzo (2017) Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis. European Geriatric Medicine, 8 (2). pp. 117-122. ISSN 1878-7649

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Official URL: http://dx.doi.org/10.1016/j.eurger.2017.01.002

Abstract

Background/aim: Deficiency of acetyl-L-carnitine (ALC) and L-carnitine (LC) appears to play a role in peripheral diabetic neuropathy, although the evidence in humans is still limited. We conducted a systematic review and meta-analysis investigating the effect of ALC on pain and electromyographic parameters in people with diabetic neuropathy. Methods: A literature search in major databases, without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) or pre- and post-test studies. The effect of ALC supplementation on pain perception and electromyographic parameters in patients with diabetic neuropathy was compared vs. a control group (RCTs). The effect of ALC/LC on electromyographic parameters were also calculated vs. baseline values. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes. Results: Six articles, with a total of 711 diabetic participants, were included. Three RCTs (340 treated with ALC vs. 203 placebo and 115 with methylcobalamine) showed that ALC reduces pain perception (SMD = −0.45; 95% CI: −0.86 to −0.04; P = 0.03; I2 = 85%). Compared to controls, ALC supplementation improved nerve conduction velocity and amplitude response for ulnar nerve (both sensory and motor component). Compared to baseline values, ALC/LC supplementation improved nerve conduction velocity for all the sensory and motor nerves (except ulnar and peroneal) investigated and the amplitude of all nerves. The onset of adverse events was generally limited to minor side effects. Conclusion: ALC appears to be effective in reducing pain due to diabetic neuropathy compared to active or placebo controls and improving electromyographic parameters in these patients.

Item Type: Journal Article
Keywords: acetyl-L-carnitine, neuropathy, diabetes, meta-analysis
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Brendon Stubbs
Date Deposited: 10 Feb 2017 12:02
Last Modified: 27 Nov 2017 14:19
URI: http://arro.anglia.ac.uk/id/eprint/701454

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