Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis

Veronese, Nicola and Cereda, Emanuele and Stubbs, Brendon and Solmi, Marco and Luchini, Claudio and Manzato, Enzo and Sergi, Giuseppe and Manu, Peter and Harris, Tamara and Fontana, Luigi and Strandberg, Timo and Amieva, Helene and Dumurgier, Julien and Elbaz, Alexis and Tzourio, Christophe and Eicholzer, Monika and Rohrmann, Sabine and Moretti, Claudio and D’Ascenzo, Fabrizio and Quadri, Giorgio and Polidoro, Alessandro and Lourenço, Roberto A. and Moreira, Virgilio G. and Sanchis, Juan and Scotti, Valeria and Maggi, Stefania and Correll, Christoph U. (2017) Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing Research Reviews, 35. pp. 63-73. ISSN 1872-9649

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Official URL: http://dx.doi.org/10.1016/j.arr.2017.01.003

Abstract

Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR = 1.70 [95%CI, 1.18-2.45]; I2 = 66%) and pre-frail (HR = 1.23 [95%CI, 1.07-1.36]; I2 = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults.

Item Type: Journal Article
Keywords: frailty, cardiovascular disease, meta-analysis
Faculty: ARCHIVED Faculty of Health, Social Care & Education (until September 2018)
Depositing User: Brendon Stubbs
Date Deposited: 10 Feb 2017 12:14
Last Modified: 07 Jan 2019 12:12
URI: http://arro.anglia.ac.uk/id/eprint/701453

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